Yasutoshi Koga Selected Research

MELAS Syndrome (Syndrome, MELAS)

1/2020	Arginine therapy in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes.
1/2019	Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial.
1/2019	Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease.
12/2018	Therapeutic regimen of L-arginine for MELAS: 9-year, prospective, multicenter, clinical research.
8/2016	L-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS.
1/2016	Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes.
1/2016	Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes.
1/2015	GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases.
1/2014	[The treatment of mitochondrial disorders, present and future].
5/2012	Molecular pathology of MELAS and L-arginine effects.

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Yasutoshi Koga Research Topics

Disease

19	Mitochondrial Diseases (Mitochondrial Disease) 03/2022 - 02/2006
16	MELAS Syndrome (Syndrome, MELAS) 01/2020 - 03/2003
6	Stroke (Strokes) 01/2019 - 02/2007
3	Cardiomyopathies (Cardiomyopathy) 10/2019 - 03/2010
3	Diabetes Mellitus 01/2016 - 01/2016
3	Lactic Acidosis 01/2014 - 02/2006
2	Neoplasms (Cancer) 01/2022 - 10/2019
2	Heart Failure 01/2020 - 10/2019
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 10/2016
2	Muscular Diseases (Myopathy) 02/2018 - 01/2016
2	Precocious Puberty 01/2017 - 01/2016
2	Leigh Disease (Leigh's Disease) 02/2012 - 03/2010
1	Developmental Disabilities (Developmental Disability) 03/2022
1	Fanconi Syndrome (Syndrome, Fanconi) 03/2022
1	Brain Diseases (Brain Disorder) 01/2022
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2022
1	Autoimmune Hepatitis 01/2022
1	Muscle Hypotonia (Hypotonia) 01/2022
1	Fibrosis (Cirrhosis) 01/2022
1	Liver Diseases (Liver Disease) 01/2022
1	Myoclonus (Nocturnal Myoclonus) 01/2022
1	Birth Weight (Birth Weights) 11/2021
1	Congenital Heart Defects (Congenital Heart Defect) 01/2020
1	Muscle Weakness 10/2019
1	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 10/2019
1	Body Weight (Weight, Body) 10/2019
1	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 10/2019
1	Neuromyelitis Optica (Devic's Disease) 10/2019
1	Multiple Sclerosis 10/2019
1	Headache (Headaches) 12/2018
1	Vomiting 12/2018
1	Nausea 12/2018
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 02/2018
1	Hypothalamic hamartomas 01/2016
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 01/2016
1	Type 2 Diabetes Mellitus (MODY) 01/2016
1	Diarrhea 01/2016
1	Hypoglycemia (Reactive Hypoglycemia) 01/2016
1	Cognitive Dysfunction 01/2016
1	Hyperthyroidism 08/2012
1	Graves Disease (Basedow Disease) 08/2012
1	Mitochondrial cytopathy 05/2012
1	Epilepsy (Aura) 02/2012
1	Cytochrome-c Oxidase Deficiency 03/2010
1	Infections 03/2010
1	Neurodegenerative Diseases (Neurodegenerative Disease) 03/2010
1	Acidosis 02/2006
1	Pyruvate Dehydrogenase Complex Deficiency Disease 02/2006
1	Migraine Disorders (Migraine) 10/2005
1	Leber Hereditary Optic Atrophy (Leber's Hereditary Optic Neuropathy) 06/2005
1	Carcinogenesis 05/2005

Drug/Important Bio-Agent (IBA)

9	Pyruvic Acid (Pyruvate)IBA 10/2019 - 12/2007
8	Growth Differentiation Factor 15IBA 01/2022 - 01/2015
8	Mitochondrial DNA (mtDNA)IBA 01/2022 - 06/2005
8	Biomarkers (Surrogate Marker)IBA 11/2021 - 01/2015
8	Arginine (L-Arginine)FDA Link 01/2020 - 02/2007
6	SodiumIBA 10/2019 - 03/2010
5	Lactic Acid (Lactate)FDA LinkGeneric 11/2021 - 03/2010
4	EnzymesIBA 03/2022 - 10/2005
4	Leu Transfer RNAIBA 01/2019 - 02/2008
3	DNA (Deoxyribonucleic Acid)IBA 10/2016 - 03/2010
2	Transforming Growth Factor beta (TGF-beta)IBA 01/2020 - 10/2019
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2020 - 11/2008
2	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 01/2017 - 01/2016
2	Proteins (Proteins, Gene)FDA Link 10/2016 - 05/2005
2	Mitochondrial Proteins (Mitochondrial Protein)IBA 10/2016 - 03/2015
2	Insulin (Novolin)FDA Link 01/2016 - 01/2016
2	Therapeutic UsesIBA 02/2012 - 02/2007
1	Electron Transport Complex III (Coenzyme Q-Cytochrome-c Reductase)IBA 03/2022
1	Adenine Nucleotide Translocator 1IBA 01/2022
1	Anticonvulsants (Antiepileptic Drugs)IBA 01/2022
1	Brain Natriuretic Peptide (Natrecor)FDA Link 11/2021
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 01/2020
1	Acyl-CoA Dehydrogenase (Medium-Chain Acyl-Coenzyme A Dehydrogenase)IBA 10/2019
1	coenzyme Q10 (CoQ10)IBA 10/2019
1	Taurine FDA Link 01/2019
1	NucleotidesIBA 01/2019
1	AnticodonIBA 01/2019
1	Codon (Codons)IBA 01/2019
1	Dihydrotachysterol (AT 10)IBA 12/2018
1	DesminIBA 02/2018
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2016
1	fibroblast growth factor 21IBA 01/2016
1	Glucagon-Like Peptide-1 ReceptorIBA 01/2016
1	Insulin Glargine (Lantus)FDA Link 01/2016
1	Liraglutide FDA Link 01/2016
1	Biological ProductsIBA 01/2016
1	Glucose (Dextrose)FDA LinkGeneric 01/2016
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2016
1	Methylphenidate (Ritalin)FDA LinkGeneric 01/2016
1	Pharmaceutical PreparationsIBA 01/2014
1	Thyroid HormonesIBA 08/2012
1	Methimazole (Thiamazole)FDA LinkGeneric 08/2012
1	IodineIBA 08/2012
1	Alanine (L-Alanine)FDA Link 02/2012
1	Transfer RNA (tRNA)IBA 02/2006

Therapy/Procedure

12	Therapeutics 01/2020 - 02/2007
2	Glycemic Control 01/2016 - 01/2016
2	Oral Administration 11/2008 - 02/2007
1	Intravenous Administration 12/2018